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Many undergraduate students understand that model organisms are important for understanding how biology works, but may not make the connection that animal models such as Drosophila melanogaster can be used to understand such human conditions as Alcohol Use Disorder (AUD) and Fetal Alcohol Syndrome (FAS). To address this knowledge gap, we introduced an inquiry-based laboratory module in which students perform hands-on Ethanol Behavior Mobility Assays (EMBAs) using flies with either different Alcohol Dehydrogenase (ADH) alleles or different developmental exposure to ethanol. The lab module contains a bioinformatic component for students to explore the evolutionary conservation of the ADH gene between flies and humans. The implementation of this exercise in a sophomore/junior-level Genetics course led to a high level of student satisfaction and a more integrated view of the role of model organisms in studying AUD and FAS. Funding acknowledgements: ABLE Roberta Williams Laboratory Teaching Initiative Grant and NSF HBCU-UP TIP Grant # 1912188. 

Many undergraduate students understand that model organisms are important for understanding how biology works, but may not make the connection that animal models such as Drosophila melanogaster can be used to understand such human conditions as Alcohol Use Disorder (AUD) and Fetal Alcohol Syndrome (FAS). To address this knowledge gap, we introduced an inquiry-based laboratory module in which students perform hands-on Ethanol Behavior Mobility Assays (EMBAs) using flies with either different Alcohol Dehydrogenase (ADH) alleles or different developmental exposure to ethanol. The lab module contains a bioinformatic component for students to explore the evolutionary conservation of the ADH gene between flies and humans. The implementation of this exercise in a sophomore/junior-level Genetics course led to a high level of student satisfaction and a more integrated view of the role of model organisms in studying AUD and FAS. Funding acknowledgements: ABLE Roberta Williams Laboratory Teaching Initiative Grant and NSF HBCU-UP TIP Grant # 1912188.